Curriculum Vitae
Current
Senior Research & Development Program Manager, Precision Neuroscience, Mountain View, CA - April 2023-present
Experience
Program Manager, Consumer Health Research, Fitbit, Google, Mountain View, CA - March 2022 - April 2023
Lead Program Manager, Pathology, HealthAI, Google, Palo Alto, CA - May 2018 - March 2022
Senior Research & Development Program Manager, Precision Neuroscience, Mountain View, CA - April 2023-present
Experience
Program Manager, Consumer Health Research, Fitbit, Google, Mountain View, CA - March 2022 - April 2023
- Lead a team to execute human subjects research studies that fuel algorithm development for health & wellness features
- Managed two program managers to drive study execution
- Drove tight cross-coordination with Research, Eng, Clinical, Clinical Operations, Legal, Privacy, Regulatory, Compliance, CROs to complete studies on time and in budget
- Landed process improvements to streamline dependencies: ex: consolidate multiple Privacy and Legal reviews into one
- Built infrastructure to ingest data in compliance with Security, Privacy and Legal guidelines
- Managed a four person team executing Data Labeling that enables algorithm development and iteration
- Managed budget, prioritize and parallelize labeling requests, established standard process for guideline development and rater training, drove feature development for labeling infrastructure
Lead Program Manager, Pathology, HealthAI, Google, Palo Alto, CA - May 2018 - March 2022
- Lead Program Manager for a research team that has published 25 papers aiming to improve patient outcomes by applying artificial intelligence to digital pathology workflows
- Built Data Labeling operations from the ground up; coordinated up to 50 pathologists providing ~400k reviews over 4 years
- Stood up Quality Assurance program and Model Evaluation framework to ensure high quality labels and rapid model iteration
- Supported infrastructure team to build custom digital pathology platform
- Drove engineering work prioritization and feature improvements; ex: custom viewer features and tools, annotation storage schema
- Ensured compliance with data security and privacy requirements
- Managed all data ingestion, catalogue and use
- Automated manual task management and assignment using Google Apps Script/Javascipt and Python to reduce active work time from hours/week to min/week
- Ran quarterly OKR planning across 9 projects and 3 partnerships, drove project timelines and proactively mitigated risks, created and maintained comprehensive documentation around processes and datasets
- Supported multiple partnerships spanning 3 different organizations (Google Health, Google Cloud, Verily)
- Managed deep integration with Verily Pathology team (collectively Alphabet Pathology), ensuring clear cross-org communications across Research teams, Finances and Partnerships teams and supporting partnerships to deploy our algorithms (ex: Lumea)
- Provided program support and served as Subject Matter Expert in Annotations and Digital Pathology infrastructure use cases for standing up Cloud-based Digital Pathology Infrastructure (with Google Cloud)
- Provided program support for Cloud partnership with the Defense Innovation Unit focused on deployment of an Augmented Reality Microscope to bring AI to the bench
- Assigned to the Medical Brain team, focused on Pathology
- I originated the SSM position at Science Exchange, and spearheaded the development of multiple validation-related projects, including the Reproducibility Project: Cancer Biology, the Movember Foundation-PCF Scientific Reproducibility Initiative and independent reagent and results validation. I led a team of three colleagues; together we worked closely with original study authors replicating labs to design and carry out replication protocols, coordinate reagent transfer and facilitate communication. Each study results in a Registration Report and a Replication Study published in high profile journals (ex: eLife).
- I was an internal scientific expert, supporting our Customer Support and Sales teams. I worked closely with our product designers and developers to improve the layout and content of the site. For example, I organized 2200 service offerings into a structured hierarchy so that scientists could browse all of our service offerings and see related services.
- Expanded analysis of Myb in multiciliogenesis and submitted manuscript for publication while continuing experiments.
- Exploring the development of the mouse lung by examining transcription factors involved in cell fate specification in the lab of Dr. Mark Krasnow. I identified a transcription factor, c-myb, that is expressed in developing multiciliated cells of the mouse airway epithelium. When c-myb is selectively deleted from developing airway epithelium, there is a marked delay in centriole amplification and Foxj1 expression, two key events in the multiciliogenesis program. Expression and action of c-myb appear to be conserved across multiciliated cell types and across species.
Education
Doctor of Philosophy in Biochemistry, Stanford University School of Medicine, Stanford, CA - 2011
Doctor of Philosophy in Biochemistry, Stanford University School of Medicine, Stanford, CA - 2011
- Dissertation: c-Myb controls the initiation of ciliogenesis in the developing mouse airway epithelium
- Honors Thesis: Carapacial ridge and costal bone formation in the carapace of the red-eared slider turtle, Trachemys scripta
Selected Publications
- Gamble, P., Jaroensri, R., Wang, H. et al. Determining breast cancer biomarker status and associated morphological features using deep learning. Commun Med 1, 14 (2021). https://doi.org/10.1038/s43856-021-00013-3
- Nagpal K, Foote D, Tan F, et al. Development and Validation of a Deep Learning Algorithm for Gleason Grading of Prostate Cancer From Biopsy Specimens. JAMA Oncol. 2020;6(9):1372–1380. doi:10.1001/jamaoncol.2020.2485
- Errington TM, Iorns E, Gunn W, Tan FE, Lomax J and Nosek BA. 2014. An open investigation of the reproducibility of cancer biology research. eLife 2014;3:e04333.
- Tan F, Vladar EK, Fuentealba L, Hoh R, Ma L, Espinoza FH, Axelrod JD, Alvarez-Buylla A, Stearns T, Kintner C and Krasnow MA. 2013. Myb promotes centriole amplification and later steps of the multiciliogenesis program. Development 140(20);4277-86. doi: 10.1242/dev.094102.
- Cebra-Thomas J, Tan F, Sistla S, Estes E, Bender G, Kim C, Riccio P and Gilbert SF. 2005. How the turtle forms its shell: a paracrine hypothesis of carapace formation. J Exp Zool B Mol Dev Evol 15;304(6): 558-569. doi: 10.1002/jez.b.21059
- full list here
Professional Presentations
- Panelist, "The future of open and reproducible science", Future of Research San Francisco Symposium, 2015. San Francisco, CA.
- "c-Myb controls proper initiation of ciliogenesis in the developing mouse airway epithelium." February 2011. PhD Oral exam, Stanford, CA.
- "c-Myb controls proper initiation of ciliogenesis in the developing mouse airway epithelium." April 2011. Cell and Molecular Biology research symposium, Stanford, CA.
- "The role of the ribs in turtle shell development." Tan F. Poster presentation at the Society for Integrative and Comparative Biology annual meeting, 2003.
- "The turtle shell as co-opting developmental programs of the vertebrate head." Bender G, Tan F, Sistla S. Integr Comp Biol 42(6); 1194. Poster presentation at the Society for Integrative and Comparative Biology annual meeting, 2002.
Additional Research Experience
Honors Thesis research, Swarthmore College, 2001-2004
Honors Thesis research, Swarthmore College, 2001-2004
- Identifying developmental pathways deployed during carapace formation in the red-eared slider turtle, Trachemys scripta, with Dr. Scott F. Gilbert and Dr. Judy Cebra-Thomas. I localized an expression domain of fgf8 in the distal tips of the ribs as they enter the carapacial bulge, complementary to fgf10 expression in the carapacial bulge. This led to our hypothesis for the mechanism of carapacial outgrowth through reciprocal Fgf8/Fgf10 signaling. I tested this hypothesis using cultured embryonic turtle trunk regions and demonstrated that inhibition of Fgf signaling blocked bulge outgrowth.
- Examining the role of Shh pathway components in limb development in Dr. Lee Niswander's lab. I tested candidate genes that had shown differential expression across the anterior-posterior axis of the limb by assessing their expression using wholemount in situ hybridization.
Leadership Experience
Member Recruitment, BenchWise.org, Stanford, CA January 2013-present
Member Recruitment, BenchWise.org, Stanford, CA January 2013-present
- Feature Development Lead: Coordinated with founder and UX/UI designers to create the look, feel and content of a major upgrade to BenchWise. Integrated new features based on team and member feedback.
- Member Recruitment and Communication: Doubled membership to 1000 in 3 months. Contacted principal investigators at schools to promote BenchWise. Responded to member feedback and implemented member suggestions. Planned, led and executed recruitment and review posting drives.
- The Stanford Summer Research Program brings talented undergraduates from minority backgrounds to Stanford for a summer research internship. I worked with the students on their presentation skills, both oral and visual. Both oral and poster presentations were given at a symposium capping the program. I worked closely with the Program director and my fellow PAs to ensure the smooth operation of the program, acted as a liaison between the students and their lab mentors, and supported the students in their research endeavors.
- Student Academic Mentors are a group of students selected by the Dean's office and trained in peer-to-peer mentoring in curriculum-specific topics and general time and stress management techniques. I mentored students one-on-one and ran workshops on topic-specific skill sets, including note-taking, presentation skills, organizational skills and biology-related tips and tools.
- I served as a TA for numerous biology classes, including intro level Bio 101 and an upper level evolutionary development seminar. I was responsible for directing laboratory experiments and mentoring students in lab. I also TAed an introductory astronomy course, where I helped students with questions and graded homework assignments.
Techniques and Skills
Computer skills
Computer skills
- Project Mangement software (ex: Asana, Google Sheets, Smartsheet), Google Apps Script (Javascript), Python
- immunohistochemistry/immunofluorescence (wholemount and section), in situ hybridization (colorimetric and fluorescent), confocal microscopy, epifluorescent microscopy, tissue harvesting, fixation and processing (paraffin and OCT embedding, vibratome and microtome sectioning), high throughput image based expression pattern screening, luciferase assays
- primary tissue culture, cell line culture, transfection, viral production and infection, BSL2+ level
- PCR, molecular cloning, nucleic acid purification and analysis, DNA sequencing
- adult and embryonic mouse dissection, mouse genetics, mouse colony maintenance, non-model organism (turtle) dissection and maintenance
Personal interests
singing in the a cappella group Redshift, learning on Coursera.org, reading, indoor rock climbing, cooking and baking, candle-making, traveling, board games, gardening, Legos
singing in the a cappella group Redshift, learning on Coursera.org, reading, indoor rock climbing, cooking and baking, candle-making, traveling, board games, gardening, Legos